MTHP

Overview

MTHP (4-Methyltetrahydropyran) has high polarity and high phase separation with water, as well as high stability. Therefore, it contributes to process improvements in chemical reactions, post-processing, and extraction.

Reaction Solvent

Organometallic reactions (e.g., Grignard reaction)
Transition metal-catalyzed reactions (e.g., Suzuki-Miyaura coupling)
Alternatives to aromatic and halogenated solvents
Others (e.g., Azeotropic dehydration, Peptide synthesis)

High Polarity: MTHP can be used in reactions requiring polar solvents, such as organometallic reactions.
Excellent Phase Separation with Water: MTHP allows for the entire reaction and post-processing steps to be carried out with a single solvent. High extraction yield. MTHP reduces organics in wastewater.
High Stability Against Acids, Bases, and Oxidation: Low risk of by-product formation, contributing to the acquisition of high-purity target compounds.
Depending on the reaction and substrate, it can achieve higher reaction yields compared to other ether-based solvent systems.
MTHP allows extremely low-temperature reactions to be carried out at milder temperatures.

	BP (^oC)	MP (^oC)	Specific gravity (20^oC,g/cm³)	Viscosity (cP)	Flash point (^oC)	Solubility in water (wt%)	Water solubility (wt%)	Azeotropic point (^oC) (H₂O ratio)	SP value* (cal/cm³)^0.5
MTHP	105	-92	0.86	0.78	6.5	1.5	1.4	85 (19wt%)	9.0
THF	65	-109	0.89	0.55	-15	∞	∞	64 (6.0wt%)	9.5
2MTHF	80	-136	0.85	0.60	-11	14	4.4	71 (11wt%)	8.9
CPME	106	-140	0.86	0.55	-1	1.1	0.3	83 (16wt%)	8.4
Et₂O	34.6	-116	0.70	0.24	-45	6.5	1.2	34 (1.3wt%)	7.6
1,4-Dioxane	101	12	1.04	1.30	11	∞	∞	88 (18wt%)	10.0

MTHP

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Characteristics

Standard grades and properties

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